Touching up antibodies prevents autoimmunity

Like the first draft of a term paper, the antibody genes of some B cells require revisions. On page 2985, Panigrahi et al. show that this genetic editing is faulty in patients with two kinds of autoimmune disease. The results could lead to new tests and refined treatments for these diseases. During development in the bone marrow, maturing B cells reshuffle their antibody genes to fashion defens...

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Abundance of ITAM prevents autoimmunity

Robo keeps axons moving F or migrating axons, attraction becomes repulsion with the fl ip of an alternatively spliced switch, according to Zhe Chen, Marc Tessier-Lavigne (Genentech Inc., San Francisco, CA), and colleagues. A melange of chemoattractants and repellants guides growing axons to their targets. Axons that cross the midline of the spinal cord on their way toward the nascent brain, how...

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Propranolol Prevents Osteoporosis and up-regulates Leptin in Ovariectomized Rats

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

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Antinuclear antibodies defining autoimmunity pathways

Immunofluorescent imaging has been a powerful technique in helping to identify intracellular nuclear and cytoplasmic molecules which are target antigens of autoantibodies in systemic autoimmune disorders. Patterns of staining can be correlated with molecules engaged in specific cellular functions and distributed in distinct cellular domains. Different autoimmune disorders have different profile...

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Propranolol Prevents Osteoporosis and up-regulates Leptin in Ovariectomized Rats

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

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Touching up antibodies prevents autoimmunity

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